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Genes & Covid-19 severity
A recent genome-wide association study (Ellinghaus et al., 2020) has identified genetic variations in two loci associated with severe Covid-19 outcome.
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Response to SARS-CoV-2
Explore transcriptional response of host cells to infection with the novel SARS-Cov-2 virus in GENEVESTIGATOR®!
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Curated COVID-19 data
Check our curated gene expression studies related to the pathology and treatment of COVID-19.
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Priming protease Furin
SARS-Cov-2 differs from closely related coronaviruses (including SARS-Cov) in the sequence of its spike protein, among other differences.
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Regulation of LY6E
Recently, Pfaender et al. (2020) reported that the lymphocyte antigen 6 complex, locus E (LY6E) protein potently restricts cellular infection by multiple coronaviruses, including SARS-CoV-2.
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Conditions regulating ACE2
Under the hypothesis that the expression level of the ACE2 receptor correlates with the degree of infection by the virus, we screened over 10,000 experimental conditions to identify those causing a strong up- or down-regulation of ACE2.