Curated studies for research on COVID-19

12 Jun 2020

Curated COVID-19 data

The number of gene expression studies related to the pathology and treatment of COVID-19 has strongly increased in the past months. Researchers characterize this disease at the molecular level using a variety of approaches and perspectives.
The following table describes high-quality human and mouse RNA-Seq and microarray studies that have been curated and integrated into GENEVESTIGATOR® for research on COVID-19. Included in this collection are primarily studies investigating molecular changes associated with SARS-CoV-2 infections, as well as secondary studies investigating experimental COVID-19 treatments (repurposed) in the context of their original use.
Stay tuned to explore more curated high-quality gene expression studies!

GENEVESTIGATOR ID Repository ID (s) Study Title Number of Samples
HS-03427 GSE47963 (superseries of GSE47960, GSE47961, GSE47962) SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures. 438
HS-03426 GSE45042 Cell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus 32
HS-03424 GSE56677 Cytokine stimulation systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates. 32
HS-03423 GSE37827 SCL006, icSARS CoV Urbani or icSARS Bat SRBD (spike receptor binding domain from the wild type strain Urbani to allow for infection of human and non-human primate cells) infections of the 2B4 clonal derivative of Calu-3 cells - Time course 87
HS-03422 GSE33267 SCL005: icSARS CoV Urbani or icSARS deltaORF6 infections of the 2B4 clonal derivative of Calu-3 cells - Time course 99
HS-03420 GSE147507 Transcriptional response to SARS-CoV-2 infection 67
HS-03375 GSE148817 (part of GSE148818) Cell-intrinsic differences between human tracheal epithelial cells from children and adults 6
HS-03244 GSE78068 Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study 209
HS-02837 GSE25160 Combination of peripheral blood gene expression profiles and clinical parameters predicts response for tocilizumab (anti-IL6) treatment in rheumatoid arthritis 26
HS-02781 GSE46293 (Superserie of GSE46280, GSE46282, GSE46283, GSE46292) Expression data of multiple sclerosis patients receiving Interferon-beta therapy 24
HS-01798 GSE56192 (part of GSE56189) Transcriptomic analysis of the Novel Middle East Respiratory Syndrome Coronavirus (Human, MRC5 cells) 25
HS-01477 GSE17183 Hepatic gene expression before and during interferon and ribavirin combination therapy 98
HS-01237 GSE45867 Effects of tocilizumab versus methotrexate therapy on gene expression profiles in the early rheumatoid arthrtis synovium 40
HS-00214 GSE7123 Gene profiling of responders and non-responders to antiviral therapies peg interferon and ribavirin against hepatitis C 341
MM-01639 GSE148829 SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues 65
MM-01637 GSE59185, GSE52920 Host responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains / GSE52920 18
MM-01636 GSE131936 Relative timing of type I interferon response and virus replication determines disease outcome during MERS-CoV infection 16
MM-01635 GSE146074 LY6E blocks coronavirus fusion and confers immune control of viral disease 36
MM-01632 GSE49262, GSE49263 SM012 - SARS MA15 wild type, and SARS deltaORF6 mutant virus infections of C57BL6 mice - A time course 75
MM-00498 GSE21583 Effects of ACE2 on BMPR2 mutation-mediated defects in gene expression 8
MM-01448 GSE84709 Expression data of Brain CD11b+ cells from WT and DP1 knockout mice infected with rJ2.2 7
MM-01140 GSE36016 Transcriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds 36
MM-01109 GSE51386 SM004 - SARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice 38

Table: These human and mouse RNA-Seq and Microarray studies in GENEVESTIGATOR® investigate gene expression changes associated with SARS-CoV-2 and changes associated with experimental treatments of COVID-19.