Explore transcriptional response of host cells to infection with the novel SARS-Cov-2 virus in GENEVESTIGATOR®! The example below shows a comparison of SARS-Cov-2 infected vs. uninfected primary cells from a recently published study (10.1016/j.cell.2020.04.026). The observed up-regulation of CCL20, IL-6, CXCL8 and other pro-inflammatory cytokines indicates that the infected cells elicit a strong chemotactic and inflammatory response.
Figure: Differential expression analysis of SARS-Cov-2 infected vs. uninfected primary human epithelial cells. GENEVESTIGATOR® volcano plot showing differentially expressed genes (up-regulated in red, down-regulated in green; top-20 up-regulated gene names shown)..