Learning from the transcriptome blog

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30 Apr 2020

Conditions regulating ACE2

Under the hypothesis that the expression level of the ACE2 receptor correlates with the degree of infection by the virus, we screened over 10,000 experimental conditions to identify those causing a strong up- or down-regulation of ACE2.

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09 Apr 2020

ACE2 versus TMPRSS2

To infect human cells, the SARS-CoV-2 receptor requires the presence of at least the ACE2 receptor (angiotensin-converting enzyme 2) and of the priming protease TMPRSS2 (transmembrane serine protease 2).

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02 Apr 2020

Tissue expression of ACE2

COVID-19 is not only a respiratory disease, it affects multiple organs and also the immune system.