Learning from the transcriptome blog

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09 Jul 2020

Genes & Covid-19 severity

A recent genome-wide association study (Ellinghaus et al., 2020) has identified genetic variations in two loci associated with severe Covid-19 outcome.

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08 Jul 2020

Response to SARS-CoV-2

Explore transcriptional response of host cells to infection with the novel SARS-Cov-2 virus in GENEVESTIGATOR®!

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29 May 2020

Priming protease Furin

SARS-Cov-2 differs from closely related coronaviruses (including SARS-Cov) in the sequence of its spike protein, among other differences.

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11 May 2020

Regulation of LY6E

Recently, Pfaender et al. (2020) reported that the lymphocyte antigen 6 complex, locus E (LY6E) protein potently restricts cellular infection by multiple coronaviruses, including SARS-CoV-2.

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30 Apr 2020

Conditions regulating ACE2

Under the hypothesis that the expression level of the ACE2 receptor correlates with the degree of infection by the virus, we screened over 10,000 experimental conditions to identify those causing a strong up- or down-regulation of ACE2.

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09 Apr 2020

ACE2 versus TMPRSS2

To infect human cells, the SARS-CoV-2 receptor requires the presence of at least the ACE2 receptor (angiotensin-converting enzyme 2) and of the priming protease TMPRSS2 (transmembrane serine protease 2).