Metabolic syndrome (MetS) is a collection of pathological conditions that include abdominal obesity, increased blood pressure, insulin resistance and increased blood glucose and lipids. MetS is a risk factor for type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). Combined, these cardio-metabolic diseases form a heavy burden on our society and health care system. Clearly, increasing our knowledge on the molecular mechanisms contributing to the maintenance of metabolic homeostasis will provide tools to improve prognosis, diagnosis and ultimately treatment of patients with cardio-metabolic diseases.
As a PhD student in EndoConnect you will be part of an international team of young researchers. You will have your individual research project at your host organisation, focusing on your discipline of interest. To broaden your specialized training, you will undertake internships at complementary EndoConnect partner organization. In addition, you will follow advanced interdisciplinary courses by leaders in the field of molecular and cell biology, metabolism, physiology and biomedical research. Thus, you will be trained to become one of the future leaders in this emerging interdisciplinary field.
For more about EndoConnect, check here.
Are you interested? Please, check the PhD position available with Nebion and Helmholtz Munich!
Open PhD Position
PhD student 9 - Transcriptional regulation and functional validation of endo-lysosomal genes in metabolic diseases
Host organisations: Nebion, Zurich, Switzerland, and Helmholtz Center Munich, Germany.
You are employed at Nebion and the research is done partly at Nebion and to a large extent at Helmholtz Munich. You will receive your degree through Helmholtz Munich and the Technical University Munich.
The PhD student will scout and curate public transcriptomic datasets of healthy, diseased and patient samples and mouse models of NAFLD/NASH with focus on liver tissue. The student will be involved in the integration of the datasets and meta-analysis to gather insights for follow-up experimental planning with emphasis on endo- lysosomal processes. Perturbation analysis will be performed to formulate the potential role of top candidates in metabolic disease. After prioritization, several candidates will be further studied in cellular and mouse models to elucidate their function in metabolic control.
Application and contact
Please submit your application including a cover letter, detailed CV, copies of your certificates as well as at least two letters of recommendation preferably per email to:
Dr. Philip Zimmermann E-Mail: firstname.lastname@example.org
Dr. Anja Zeigerer E-Mail: email@example.com
Application deadline: 31st of May 2021
Complete job description and contact information: