Example Studies

Expression of SARS-CoV-2 receptor


© NEBION AG. March 6, 2019

Research on developing therapeutic strategies against the SARS-CoV-2 virus currently has highest priority in many research facilities around the world. To better understand the pathobiology of COVID-19, we used GENEVESTIGATOR® to visualize the gene expression pattern of two human genes involved in host infection by SARS-CoV-2: angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). The top 30 of 445 human tissues and cell-types, where either of the two genes are highly expressed, are presented in figures 1 and 2.

Download the PDF for an extended visualization of ACE2 and TMPRSS2 in 445 human tissues.


Top 30 human tissues and cell-types where ACE2 is expressed

Data selected: mRNASeq samples from adult, healthy untreated subjects

post thumb Figure 1: Boxplot showing ACE2 expression in the top 30 of 445 tissues and cell types tested.


Top 30 human tissues and cell-types where TMPRSS2 is expressed

Data selected: mRNASeq samples from adult, healthy untreated subjects

post thumb

Figure 2: Boxplot showing TMPRSS2 expression in the top 30 of 445 tissues and cell types tested.


Further ideas to study the expression of genes related to COVID-19 in GENEVESTIGATOR® based on the therapeutic strategies proposed by Zhang et al., 2020:

  1. Indentify cell lines with high expression levels of ACE2 to find suitable cell lines for vaccine production.
  2. Screen for compounds downregulating either TMPRSS2 or ACE2, or genes from the same pathways as potential new targets.