NASH TRANSLATIONAL MODELS

NASH TRANSLATIONAL MODELS

By Alena Jiraskova, Anneli Andersson, Jana Sponarova, and Philip Zimmermann
Ā© NEBION AG. April 15, 2019

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic, progressive liver disease. The onset of the disease is highly associated with obesity, insulin resistance and dyslipidemia. Without intervention, the disease can progress to non-alcoholic steatohepatitis (NASH), and via fibrosis and cirrhosis, to end-stage liver disease and hepatocellular carcinoma (HCC). New technologies and more research efforts are needed to develop crucial stage-specific diagnosis, effective treatment decisions and translational models.

In this study (Download PDF), we used GENEVESTIGATORĀ® for NASH mouse model characterization and biomarker validation. GENEVESTIGATORĀ® is a tool to visualize public expression datasets curated by NEBION. It allows the user to mine thousands of experiments simultaneously to identify genes having a very specific profile, to find genes associated with diseases, to characterize targets and biomarkers, or to find indications associated with the transcriptional activity of selected genes.