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SARS-CoV-2 and cholesterol
A recent pre-print study has identified several drugs that block SARS-CoV-2 replication based on their ability to counteract the virus-induced transcriptional landscape.
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Curated COVID-19 data
NEBION continuously curates COVID-19 related gene expression studies and integrates them into GENEVESTIGATOR®.
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Genes & Covid-19 severity
A recent genome-wide association study (Ellinghaus et al., 2020) has identified genetic variations in two loci associated with severe Covid-19 outcome.
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Response to SARS-CoV-2
Explore transcriptional response of host cells to infection with the novel SARS-Cov-2 virus in GENEVESTIGATOR®!
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Priming protease Furin
SARS-Cov-2 differs from closely related coronaviruses (including SARS-Cov) in the sequence of its spike protein, among other differences.
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Conditions regulating ACE2
Under the hypothesis that the expression level of the ACE2 receptor correlates with the degree of infection by the virus, we screened over 10,000 experimental conditions to identify those causing a strong up- or down-regulation of ACE2.